Mpox (Monkeypox)


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Information is being updated as it becomes available. 

Mpox Cases in Fresno County

Vaccine Allocation: Mpox vaccine administration data in Fresno County

What is Mpox?

Mpox is a rare disease that is caused by infection with the Mpox virus. Mpox virus belongs to the Orthopoxvirus genus in the family Poxviridae. The Orthopoxvirus genus also includes variola virus (which causes smallpox) and cowpox virus. 

Mpox was first discovered in 1958 when two outbreaks of pox-like disease occurred in colonies of monkeys kept for research, hence the name "Monkeypox."  The first human case of MPX was recorded in 1970 in the Democratic Republic of the Congo (DRC) during a period of intensified effort to eliminate smallpox.

What are the Signs and Symptoms?

In humans, the symptoms of Mpox are similar to, but milder than the symptoms of smallpox.  The main difference between symptoms of Mpox and smallpox is that Mpox causes lymph nodes to swell while smallpox does not. Mpox illness starts with the following symptoms:

  • Fever
  • Headache
  • Muscle aches  
  • Backache
  • Swollen lymph nodes
  • Chills
  • Exhaustions 

Within 1 to 3 days after the appearance of fever, the patient develops a rash, beginning on the face then spreading to other parts of the body. The illness usually lasts for 2 to 4 weeks. Lesions progress through the following stages before falling off:

  • Macules
  • Papules
  • Vesicles
  • Pustules
  • Scabs

How does Mpox spread?

Mpox spreads in different ways. The virus can spread from person-to-person through:

  • Direct contact with the infectious rash, scabs, or body fluids.
  • Respiratory secretions during prolonged, face-to-face contact, or during intimate physical contact, such as kissing, cuddling, or sex.
  • Touching items (such as clothing or linens) that previously touched the infectious rash or body fluids.
  • Pregnant people can spread the virus to their fetus through the placenta.


What is the incubation period of Mpox?

  • The incubation period (time from infection to symptoms) for Mpox is usually 7 to 14 days but can range from 5 to 21 days. 
  • Infection with Mpox virus begins with an incubation period. A person is not contagious during this period; they do not have symptoms and may feel fine.

California Department of Public Health (CDPH) MPX Guidance for Isolation:   



Who is at risk for severe disease from Mpox?

  • Immunocompromised individuals.
  • Pediatric populations, particularly patients younger than 8 years of age.
  • Pregnant or breastfeeding women.
  • People with a history or presence of atopic dermatitis and people with other active skin conditions such as eczema, burns, impetigo, and varicella zoster virus infection.


How to prevent Mpox infection?

  • Avoid contact with animals that could carry the virus (including animals that are sick or that have been found dead in areas where Mpox occurs).
  • Avoid contact with any materials, such as bedding, that has been in contact with an infected individual.
  • Isolate infected patients from others.
  • Practice good hand hygiene by washing your hands with soap and water frequently for at least 20 seconds or by using an alcohol-based hand sanitizer.
  • Use personal protective equipment (PPE) when caring for patients.     


How is Mpox diagnosed?

  • The presence of swollen lymph nodes during the prodromal stage of illness can be used to distinguish Mpox from other rash illnesses such as chickenpox, measles, bacterial skin infections, scabies, syphilis, and medication-associated allergies.
  • If Mpox is suspected, healthcare workers can collect a sample and send it to the lab for testing. Polymerase chain reaction (PCR) is the preferred test because of its accuracy and sensitivity. The samples used for testing Mpox are taken from skin lesions.  


What is the treatment for Mpox?

Currently there is not a specific treatment approved for Mpox virus infections. However, antivirals developed for use in patients with smallpox may prove beneficial. There are no treatments specifically for Mpox virus infections. However, Mpox and smallpox viruses are genetically similar, which means that antiviral drugs and vaccines developed to protect against smallpox may be used to prevent and treat Mpox virus infections.

If you have symptoms of Mpox, you should talk to your healthcare provider, even if you don’t think you had contact with someone who has Mpox.


What should I do if I think I have Mpox?




Educational Materials:

Mpox Quick Facts(PDF, 106KB)

(Español(PDF, 111KB))

FCDPH- Monkeypox Quick Facts ENGLISH 8.18.22(PDF, 106KB)

Mpox Vaccine Eligibility(PDF, 77KB)

(Español(PDF, 85KB))

   Monkeypox Vaccine Elig7.26.22(PDF, 77KB)

Mpox Vaccine Clinics(PDF, 333KB)

(Español(PDF, 378KB))

Monkeypox Vaccine Clinics ENGLISH 8.17.22(PDF, 333KB)

Mpox Cleaning and Disinfecting(PDF, 294KB)

(Español(PDF, 301KB))

FCDPH- Cleaning and Disinfecting for Monkeypox ENGLISH 8.18.22(PDF, 294KB)

Mpox Vaccine FAQs(PDF, 740KB)

(Español(PDF, 733KB))

      monkeypox faq updated(PDF, 740KB)

Mpox Close Contacts(PDF, 1MB)

(Español(PDF, 631KB))

FCDPH- Monkeypox Close Contacts ENGLISH 9.2.22(PDF, 1MB)

Mpox Information Sheet


CDPH- Monkeypox Factsheet ENGLISH 8.2022

Safer Sex and Mpox(PDF, 563KB)

(Español(PDF, 540KB))

   (PDF, 563KB)

Mpox Information for Teens and Young Adults



Learn about Mpox and Safer Sex





What You Need to Know


   CDPH- Monkeypox LGBT ENGLISH June 2022